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Effect of fenretinide (top panel, A; FEN: fenretinide+placebo or fenretinide+tamoxifen) and tamoxifen (top panel B; TAM: tamoxifen+placebo and tamoxifen+fenretinide) and homeostasis model assessment (HOMA) index. The histograms indicate the percentage of subjects improving their HOMA index from baseline, shifting from HOMA ≥ 2.8 to HOMA < 2.8. Two years treatment followed by one year follow-up.
