Table 5 Disorders that may lead to increasing frailty and potential treatments.

Condition/disorder	Treatment
Falls/fractures	Vitamin D
	Calcium treatment
	Exercise
Depression	Exercise
	Social interaction
	Counselling
	Psychotherapy
	Antidepressants
Lowered testosterone (males)	Replacement therapy
Cognitive impairment	Cholinesterase inhibitors
	Exercise
Hypothyroidism	L‐thyroxine
Inflammation/muscle strength	Exercise
	Statins/ACE inhibitors
Type 2 diabetes	Thiazolidinedione
	Anti‐glycaemics
Blood‐clotting activity	Aspirin
Poor nutrition	Dietary regulation
CHD	Antihypertensives
	Aspirin
	Statins
Anaemia	Haematinic replacement therapy
	Recombinant human erythropoietin
Arthritis	NSAIDs
	Steroids

ACE, angiotensin‐converting enzyme; CHD, coronary heart disease; NSAIDs, non‐steroidal anti‐inflammatory drugs.