Table 1 Desmopressin use in various types of von Willebrand disease.

Type of VWD	Characteristic features	Desmopressin use
Type 1	Mild to moderate decrease in plasma VWF levels with a normal multimer pattern	Trial needed before use
Type 2A	Absence of multimers with high and intermediate molecular weight	Trial needed before use
Type 2B	Increased affinity for platelet receptors, ultimately leading to excessive platelet activation and thrombocytopenia	Trial needed before use? Contraindicated
Type 2N	Mutation in FVIII‐binding region of the VWF, disrupting FVIII‐carrying function	Trial needed before use
Type 2M	Mutation in the region of the VWF that binds to platelet receptors, disrupting platelet adhesion	Trial needed before use
Type 3	Undetectable levels of the VWF with severe bleeding diathesis	Not useful

FVIII, coagulation factor VIII; VWD, von Willebrand disease; VWF, von Willebrand factor.