| Strict patient selection |
| Patients with histologically confirmed ulcerative colitis and at least 8 years duration in clinical remission |
| Avoid patients with active disease |
| Unmask the mucosal surface |
| Optimise bowel preparation |
| Remove mucus and remaining fluid in the colon |
| Reduce peristaltic waves |
| On extubation a spasmolytic agent should be used if necessary |
| Full‐length staining of the colon (pan‐chromoscopy) |
| Augmented detection with dyes |
| Intravital staining with 0.4% indigo carmine or 0.1% methylene blue should be used to unmask flat lesions (Paris 0‐II) more frequently than is possible with conventional colonoscopy |
| Crypt architecture analysis |
| All lesions should be analysed according to the pit pattern classification. |
| Whereas pit patterns type I and II suggest the presence of non‐neoplastic lesions, staining patterns III‐V suggest the presence of intraepithelial neoplasia (IN) ± cancer. |
| Endoscopic targeted biopsies |
| Targeted biopsies should be taken of all mucosal alterations, particularly of circumscribed lesions with staining patterns including intraepithelial neoplasias and suspected carcinomas (crypt type III‐V) |
