Table 1 Causes of lack of response to thyroxine replacement in hypothyroid patients.
| Impaired absorption | Increased clearance | Increased demand | Most common |
|---|---|---|---|
| Dietary fibre (bread) | Phenobarbital | Pregnancy | Non‐compliance |
| Bile acid sequestering agents | PhenytoinCarbamazepine | Weight gain | |
| Sucralfate | Rifampicin | ||
| Omeprazole | |||
| Soy | |||
| Herbal remedies | |||
| Small bowel disorders |