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. 2007 Oct;83(984):e1–e2. doi: 10.1136/pgmj.2007.060244

Table 1 Causes of lack of response to thyroxine replacement in hypothyroid patients.

Impaired absorption Increased clearance Increased demand Most common
Dietary fibre (bread) Phenobarbital Pregnancy Non‐compliance
Bile acid sequestering agents PhenytoinCarbamazepine Weight gain
Sucralfate Rifampicin
Omeprazole
Soy
Herbal remedies
Small bowel disorders