Table 2. Recommended Burkholderia pseudomallei postexposure antimicrobial drug prophylaxis.

Antimicrobial drug	Dosage	Frequency
Trimethoprim-sulfamethoxazole (TMP-SMX)	2 × 160–800 mg (960 mg) tablets if >60 kg, 3 × 80–400 (480 mg) tablets if 40 kg-60 kg, and 1 × 160–800 mg (960 mg) or 2 × 80–400 (480 mg) tablets if adult <40 kg plus folate 5 mg/d	Every 12 h
Doxycycline	2.5 mg/kg/dose up to 100 mg orally	Every 12 h
Amoxicillin–clavulanic acid	20/5 mg/kg/dose. Equates to 3 × 500/125 tabs if >60 kg, and 2 × 500/125 tabs if <60kg	Every 8 h