Table 3. Treatment of melioidosis.

Initial parenteral therapy

Ceftazidime 50 mg/kg/dose (up to 2 g) every 6–8 h,* or meropenem 25 mg/kg/dose (up to 1 g) every 8 h*

Duration of therapy a minimum of 10–14 d, and longer (4–8 wk) for deep-seated infection

Oral eradication therapy

Trimethoprim-sulfamethoxazole orally every 12 h 2 × 160–800 mg (960 mg) tablets if >60 kg, 3 × 80–400 (480 mg) tablets if 40–60 kg, and 1 × 160–800 mg (960 mg) or 2 × 80–400 (480 mg) tablets if adult <40 kg; ± doxycycline 2.5 mg/kg/dose up to 100 mg orally every 12 h plus folate 5 mg/d Duration at least 3–6 mo

*Plus trimethoprim-sulfamethoxazole 8/40 mg/kg (up to 320/1,600 mg) every 12 h for treatment of patients with neurologic, prostatic, bone, or joint melioidosis.