Table 2. Neutralization testing with heterologous flaviviruses of patients infected with ZIKV, Yap State, Micronesia, 2007*.
Patient | Days after onset | PRNT90 titer |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
ZIKV | DENV1 | DENV2 | DENV3 | DENV4 | JEV | YFV | WNV | SLEV | MVEV | ||
Primary flavivirus ZIKV | |||||||||||
822a | 5 | 320 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 |
822b | 10 | 2,560 | 10 | 10 | 10 | 10 | <10 | <10 | <10 | <10 | <10 |
822c | 24 | 5,120 | 10 | 10 | 10 | 10 | <10 | <10 | <10 | <10 | <10 |
830a | 2 | <10 | <10 | NT‡ | NT | NT | NT | NT | NT | NT | NT |
830b | 21 | 2,560 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 |
849a | 3 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 |
849b | 18 | 10,240 | <10 | <10 | <10 | <10 | <10 | 20 | <10 | <10 | <10 |
862a | 6 | 320 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 | <10 |
862b |
20 |
2,560 |
10 |
10 |
<10 |
<10 |
<10 |
<10 |
<10 |
10 |
<10 |
Secondary flavivirus ZIKV (probable) | |||||||||||
817a | 1 | 80 | 80 | 160 | 320 | 160 | <10 | <10 | <10 | 40 | 40 |
817b | 19 | 10,240 | 2,560 | 20,480 | 5,120 | 5,120 | 20 | 320 | 160 | 1,280 | 640 |
833a | 1 | 160 | 320 | 80 | 40 | 20 | <10 | <10 | <10 | <10 | <10 |
833b | 19 | 81,920 | 20,480 | 5,120 | 5,120 | 1,280 | <10 | <10 | 80 | 320 | 320 |
844a | 2 | 20 | 1,280 | 640 | 320 | 160 | <10 | <10 | 5 | 20 | 20 |
844b | 16 | 10,240 | 40,980 | 10,240 | 5,120 | 1,280 | 5 | <10 | 160 | 640 | 640 |
955a | 1 | 40 | 1,280 | 640 | 160 | 320 | <10 | <10 | <10 | 20 | 20 |
955b | 14 | 163,840 | 81,920 | 20,480 | 10,240 | 5,120 | 10 | <10 | 640 | 2,560 | 1,280 |
968a | 1 | 80 | 320 | 320 | 80 | 40 | <10 | <10 | <10 | 40 | 20 |
968b | 3 | 10,240 | 640 | 640 | 160 | 160 | <10 | <10 | 10 | 40 | 20 |
839a | 3 | <10 | <10 | 10 | <10 | <10 | <10 | 40 | <10 | <10 | <10 |
839b | 20 | 10,240 | 40 | 320 | 80 | 80 | <10 | 640 | 40 | 80 | 80 |
847a | 5 | <10 | <10 | <10 | <10 | <10 | <10 | 640 | <10 | <10 | <10 |
847b | 8 | 2,560 | 40 | 320 | 160 | 40 | <10 | 1,280 | 80 | 320 | 320 |
*PRNT90 titer, 90% plaque-reduction neutralization test titer; ZIKV, Zika virus; DENV, dengue virus; JEV, Japanese encephalitis virus; YFV, yellow fever virus; WNV, West Nile virus; SLEV, St. Louis encephalitis virus; MVEV, Murray Valley encephalitis virus; NT, not tested (sample depleted).