Table 1.
The nine beneficial mutations for the phage ID11 selected for rapid growth at 37°C on Escherichia coli C (Rokyta et al. 2005)
| Genome positiona |
Nucleotide substitution |
Amino acid positionb |
Amino acid substitution |
Fitnessc | SEd |
|---|---|---|---|---|---|
| Ancestor | 3.65 | 0.15 | |||
| 3864 | A → G | F421 | D → G | 4.06 | 0.16 |
| 3567 | A → G | F322 | N → S | 4.19 | 0.12 |
| 2609 | G → T | F3 | V → F | 4.39 | 0.13 |
| 3857 | A → G | F419 | T → A | 4.76 | 0.14 |
| 3543 | C → T | F314 | A → V | 4.78 | 0.15 |
| 2520 | C → T | J15 | A → V | 4.82 | 0.15 |
| 3850 | G → A/T | F416 | M → I | 4.86 | 0.15 |
| 3665 | C → T | F355 | P → S | 5.01 | 0.14 |
| 2534 | G → T | J20 | V → L | 5.08 | 0.13 |
Position corresponds to the published sequence of ID11 (GenBank accession number AY751298)
The letter indicates the gene name and the number gives the amino acid position
Fitness is measured as the log2 increase in population size per 15 min
Based on 10 replicates