Table 1.
Comparison of the non-ADAPT and ADAPT subpopulations.a
| Non-ADAPT subjects (n = 98) | ADAPT subpopulation subjects (n = 197) | P-value | |
|---|---|---|---|
| n (%) | |||
| Female (%) | 54 (55) | 91 (47) | 0.17 |
| White (%) | 96 (98) | 193 (98) | 0.68 |
| Diabetes (%) | 8 (8) | 19 (10) | 0.74 |
| Hypertension (%) | 55 (57) | 122 (62) | 0.39 |
| Hypercholesterolemia (%) | 38 (39) | 103 (52) | 0.03 |
| APOE ɛ4 allele (%) | 27 (28) | 63 (32) | 0.44 |
| Mean ± SD | |||
| Age (years) | 75.2 ± 8.21 | 76.8 ± 3.93 | 0.07 |
| Serum Aβ1–40 (pg/mL)b | 132.6 ± 49.65 | 146.3 ± 54.59 | 0.13 |
| Median [IQR] | |||
| Serum Aβ1–42 (pg/mL) | 4.9 [2.9, 9.1] | 12.0 [5.0, 22.9] | P < 0.001 |
| Serum Aβ1–42/Aβ1–40 | 0.04 [0.02, 0.07] | 0.08 [0.05, 0.15] | P < 0.001 |
a
Aβ1–40 below detection limit for 9 individuals and Aβ 1–42 below detection limit for 18 individuals.
b
Differences in Aβ1–40 between the two groups are corrected for age.