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Characteristics of the human ApoE isoforms.
| Isoform | Amino acid at position 112 158 | Allelic frequency | LDLr binding | LRP binding | VLDLr binding | Associated risk |
|---|---|---|---|---|---|---|
| ApoE2 | Cys Cys | 0.070 | No | Yes | Yes | CVD, less prone to AD? |
| ApoE3 | Cys Arg | 0.783 | Yes | Yes | Yes | – |
| ApoE4 | Arg Arg | 0.147 | Yes | Yes | Yes | AD & CVD |
AD: Alzheimer’s disease; CVD: Cardiovascular disease; LDLr: LDL receptor; LRP: LDLr-related protein; VLDLr: VLDL receptor.
