Table 1. The bodyweight of all groups of rats during the experiments.
| Time |
Body weight (g) |
||||||
|---|---|---|---|---|---|---|---|
| Group I | Group II | Group III | Group IV | Group V | Group VI | Group VII | |
| Before injection |
143± 16.17 (n=5) |
120.4±13.57 (n=9) |
116±26.7 (n=9) |
112.2±19.9 (n=9) |
116±18.48 (n=9) |
119.8±11.95 (n=9) |
112.9±18.9 (n=14) |
| 1 wk |
234.6±18.13 (n=5) |
171.6±19.7 (n=8) |
168.1±36.57 (n=8) |
146.8±30.6 (n=9) |
167±27.3 (n=9) |
157.4±23.2 (n=9) |
169±22.6 (n=13) |
| 2 wk |
283.2±17.46 (n=5) |
189.1±27.70 (n=8) |
184.6±40.59 (n=7) |
164.2±34.2 (n=9) |
187±27 (n=8) |
174.9±28.1 (n=9) |
191.6±22.6 (n=13) |
| 4 wk |
378.4±13.83 (n=5) |
191.4±61.10 (n=8) |
196.1±61.38 (n=7) |
157.2±55.1 (n=9) |
204.9±49.6 (n=8) |
159.9±43.8 (n=9) |
219.8±37.7 (n=13) |
| 5 wk |
429±15.39 (n=5) |
222±64.17 (n=8) |
231.7±69.5 (n=7) |
171.1±57.5 (n=9) |
224.3±55.4 (n=8) |
183.6±48.3 (n=9) |
227.4±52.2 (n=13) |
| 6 wk |
452±15.60 (n=5) |
232.7±66.12 (n=8) |
239.6±72.75 (n=7) |
176.4±60.8 (n=9) |
236.6±62.4 (n=8) |
188.1±50.2 (n=9) |
245.4±52.9 (n=13) |
| 7 wk |
488.6±14.28 (n=5) |
225.2±77.92 (n=8) |
240.8±83.1 (n=7) |
172.9±74.5 (n=9) |
235.4±75.3 (n=8) |
171.6±59.6 (n=9) |
238.7±68.7 (n=13) |
| 8 wk |
498±22.90 (n=5) |
233.7±87.03 (n=8) |
247.4±90.37 (n=7) |
173.3±71.9 (n=9) |
248.9±71.9 (n=8) |
184.1±66.0 (n=8) |
248.6±73.5 (n=13) |
| 9 wk |
532.6±22.31 (n=5) |
237.4±109.1 (n=8) |
254.8±99.0 (n=7) |
170.7±77.2 (n=9) |
247.6±88.6 (n=7) |
181.1±58.3 (n=7) |
236.5±90.8 (n=13) |
| 10 wk |
542.8±17.74 (n=5) |
233.8±104.2 (n=8) |
249±104.3 (n=7) |
183.0±73.9 (n=8) |
246.5±93.3 (n=7) |
168.6±60.0 (n=7) |
238.5±86.1 (n=13) |
| 11 wk |
558.4±27.79 (n=5) |
247.5±105.4 (n=7) |
265.3±102.3 (n=6) |
173.4±74.6 (n=8) |
242.3±100.1 (n=7) |
170.2±74.7 (n=6) |
257.6±83.7 (n=10) |
| 12 wk |
550±34.46 (n=5) |
244.8±112.7 (n=7) |
265.4±114.1 (n=5) |
159.9±67.9 (n=8) |
252.3±107.9 (n=7) |
143.3±54.0 (n=6) |
246.8±89.9 (n=10) |
| 13 wk | 550.4±37.70 (n=5) | 242.1±117.7 (n=7) | 289.3±104.7 (n=5) | 167.3±58.8 (n=7) | 248.1±105.0 (n=7) | 142.6±55.2 (n=5) | 244.5±89.5 (n=10) |
The data are the mean±SD. Weights are significantly different between Group I and Group II-VII after STZ injection. There are no significant differences between the treated diabetic rats (from Group II-VI) and the untreated diabetic rats (Group VII) two weeks after STZ injection. However, groups IV and VI were significantly lighter than the untreated diabetic rats from week 4 through week 13 (p<0.05). On the eighth week of diabetes, blood glucose of rat number in group V was 13.3 mmol/l (<14 mmol/l), and the rat died. Then, on the eighth week of diabetes, one rat was lost. Finally, five rats were taken out because of low blood glucose, and 14 rats were lost because of death. One rat is an overlap. The total number of rats studied was then 18. Group I: Normal; Group II: Carnosine treated (5 mg/ml); Group III: Carnosine treated (10 mg/ml); Group IV: Aspirin treated; Group V: Aminoguanidine treated (1 mg/ml); Group VI: Aminoguanidine treated (2 mg/ml); and Group VII: Untreated diabetic.