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IC50 values for GC-1008 against different TGF-β isoforms (MLEC proliferation assay)
| TGF-β isoform | GC-1008 (n = 6) |
|---|---|
| TGF-β1 (40 pM) | 1 ± 2 |
| TGF-β2 (40 pM) | 14 ± 5 |
| TGF-β3 (40 pM) | 7 ± 2 |
IC50 values are given in nM. KD values for GC-1008 against TGF-β 1 and 3 have been determined in a competition assay with TGF-β receptor type II to be 50 pM and 250 pM, respectively.
