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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Immunity. 2008 Jul 31;29(2):217–227. doi: 10.1016/j.immuni.2008.05.015

Figure 3. E2A proteins restrict HSC, MPP and LMPP proliferation.

Figure 3

(A) BrdU-incorporation in BM LSKs as determined 24 hours of in vivo exposure to BrdU. LSKs were analyzed for surface expression of Flt3 and intracellular BrdU; numbers indicate the percent of BrdU+ LSKs. The graph summarizes results of 5 independent experiments. (B) Percent of HSCs, MPPs, and LMPPs that were BrdU+ in E2A+/+ and E2A−/− mice, respectively. (C) Representative FACS analysis for Annexin-V and PI staining on cultured HSC, MPP or LMPPs cells.