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. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Mitochondrion. 2008 May 23;8(5-6):396–413. doi: 10.1016/j.mito.2008.05.003

Figure 11a and 11b — Summed spectra in brain and CSF for the 19-month old with a complex IV defect. Clinically, she demonstrated sensorineural hearing loss, seizures, cortical vision impairment, and axial hypotonia.(16×16 acquisition interpolated to 32×32, TE=288, TR=1700, FOV=16cm). Through the spectra are not corrected for the number of voxels, hence the magnitudes are larger in the upper than lower spectrum, it is appreciable by eye that greater Lac is in CSF, whereas little lactate can be seen in brain. The persistent neurochemicals in CSF (Cho, Cr+PCr, and NAA) reflect the partial tissue volume of the ventricular voxels in the axial plane, combined with the applied point-spread-function hamming filter that smoothes data spatially prior to analyses. CSF has few MRS-visible metabolites except for Lac.

Figure 11a and 11b — Summed spectra in brain and CSF for the 19-month old with a complex IV defect. Clinically, she demonstrated sensorineural hearing loss, seizures, cortical vision impairment, and axial hypotonia.(16×16 acquisition interpolated to 32×32, TE=288, TR=1700, FOV=16cm). Through the spectra are not corrected for the number of voxels, hence the magnitudes are larger in the upper than lower spectrum, it is appreciable by eye that greater Lac is in CSF, whereas little lactate can be seen in brain. The persistent neurochemicals in CSF (Cho, Cr+PCr, and NAA) reflect the partial tissue volume of the ventricular voxels in the axial plane, combined with the applied point-spread-function hamming filter that smoothes data spatially prior to analyses. CSF has few MRS-visible metabolites except for Lac.