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[3H]-Naloxone displacement by multiple opioid agonists in intact, whole CHO cells transiently expressing rpMOR (A) or hMOR (B). Agonists displaced [3H]-naloxone and bound to a single site. The Ki and Hill slope for each is shown in Table 1. Percent specific binding of [3H]-naloxone at each concentration of competitor was determined in triplicate in 3−4 independent experiments (error bars indicate S.E.M.).
