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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3467–3473. doi: 10.1158/1055-9965.EPI-08-0514

Table 3.

Genotype distribution and association with risk for pancreatic cancer

Genotype
All subjects
Subjects with history of ≥ 2 years of diabetes mellitus
Cases No. (%)
Controls No. (%)
OR (95% CI)aP
Case/control No./No,
OR (95% CI)aP
IGF1 16540 A>G
    GG 436 (55.2) 389 (54.1) 1.0 (reference) 386/380 1.0 (reference)
    AG 296 (37.5) 284 (39.5) 0.93 (0.74−1.15) 0.490 268/276 0.95 (0.76−1.19) 0.655
    AA 58 (7.3) 46 (6.4) 1.21 (0.80−1.85) 0.362 56/46 1.24 (0.82−1.90) 0.311
    A allele 0.261 0.262
IGF1 1830 C>T
    TT 380 (49.1) 362 (51.3) 1.0 (reference) 339/354 1.0 (reference)
    CT 322 (41.6) 286 (40.5) 1.05 (0.84−1.30) 0.698 288/278 1.06 (0.85−1.34) 0.587
    CC 72 (9.3) 58 (8.2) 1.28 (0.87−1.88) 0.212 68/58 1.28 (0.87−1.88) 0.218
    C allele 0.291 0.285
IGF1 −177 G>C
    GG 629 (79.1) 591 (82.0) 1.0 (reference) 565/577 1.0 (reference)
    CG 154 (19.4) 124 (17.2) 1.16 (0.89−1.52) 0.272 137/121 1.16 (0.88−1.52) 0.304
    CC 12 (1.5) 6 (0.8) 2.28 (0.78−6.61) 0.131 12/6 2.41 (0.83−6.95) 0.105
    C allele 0.112 0.094
IGF2 1280 A>G
    GG 298 (38.2) 280 (39.3) 1.0 (reference) 284/279 1.0 (reference)
    AG 373 (47.8) 335 (47.1) 1.07 (0.85−1.34) 0.556 351/328 1.10 (0.87−1.38) 0.428
    AA 109 (14.0) 97 (13.6) 1.09 (0.79−1.51) 0.615 101/94 1.14 (0.81−1.59) 0.451
    G allele 0.379 0.372
IGF2 −69 C>T
    CC 659 (83.4) 595 (82.8) 1.0 (reference) 591/578 1.0 (reference)
    CT 127 (16.1) 114 (15.9) 1.00 (0.75−1.33) 0.997 116/114 0.97 (0.73−1.30) 0.859
    TT 4 (0.5) 10 (1.4) 0.26 (0.07−1.01) 0.051 3/10 0.21 (0.04−0.97) 0.046
    T allele 0.086 0.094
IGF2 −233 C>T
    CC 661 (84.1) 597 (83.7) 1.0 (reference) 593/580 1.0 (reference)
    CT 124 (15.8) 105 (14.7) 1.07 (0.80−1.42) 0.670 114/105 1.04 (0.78−1.39) 0.797
    TT 1 (0.1) 11 (1.5) 0.07 (0.01−0.57) 0.013b 1/11 0.08 (0.01−0.65) 0.018
    T allele 0.080 0.089
a

Adjusted for age, sex, diabetes status, smoking status, and family history of cancer.

b

OR (95% CI) = 0.09 (0.01−0.89), P=0.024 with further adjustment for body mass index.