Table 3.

Genotype distribution and association with risk for pancreatic cancer

Genotype	All subjects			Subjects with history of ≥ 2 years of diabetes mellitus
	Cases No. (%)	Controls No. (%)	OR (95% CI)aP	Case/control No./No,	OR (95% CI)aP
IGF1 16540 A>G
GG	436 (55.2)	389 (54.1)	1.0 (reference)	386/380	1.0 (reference)
AG	296 (37.5)	284 (39.5)	0.93 (0.74−1.15) 0.490	268/276	0.95 (0.76−1.19) 0.655
AA	58 (7.3)	46 (6.4)	1.21 (0.80−1.85) 0.362	56/46	1.24 (0.82−1.90) 0.311
A allele	0.261	0.262
IGF1 1830 C>T
TT	380 (49.1)	362 (51.3)	1.0 (reference)	339/354	1.0 (reference)
CT	322 (41.6)	286 (40.5)	1.05 (0.84−1.30) 0.698	288/278	1.06 (0.85−1.34) 0.587
CC	72 (9.3)	58 (8.2)	1.28 (0.87−1.88) 0.212	68/58	1.28 (0.87−1.88) 0.218
C allele	0.291	0.285
IGF1 −177 G>C
GG	629 (79.1)	591 (82.0)	1.0 (reference)	565/577	1.0 (reference)
CG	154 (19.4)	124 (17.2)	1.16 (0.89−1.52) 0.272	137/121	1.16 (0.88−1.52) 0.304
CC	12 (1.5)	6 (0.8)	2.28 (0.78−6.61) 0.131	12/6	2.41 (0.83−6.95) 0.105
C allele	0.112	0.094
IGF2 1280 A>G
GG	298 (38.2)	280 (39.3)	1.0 (reference)	284/279	1.0 (reference)
AG	373 (47.8)	335 (47.1)	1.07 (0.85−1.34) 0.556	351/328	1.10 (0.87−1.38) 0.428
AA	109 (14.0)	97 (13.6)	1.09 (0.79−1.51) 0.615	101/94	1.14 (0.81−1.59) 0.451
G allele	0.379	0.372
IGF2 −69 C>T
CC	659 (83.4)	595 (82.8)	1.0 (reference)	591/578	1.0 (reference)
CT	127 (16.1)	114 (15.9)	1.00 (0.75−1.33) 0.997	116/114	0.97 (0.73−1.30) 0.859
TT	4 (0.5)	10 (1.4)	0.26 (0.07−1.01) 0.051	3/10	0.21 (0.04−0.97) 0.046
T allele	0.086	0.094
IGF2 −233 C>T
CC	661 (84.1)	597 (83.7)	1.0 (reference)	593/580	1.0 (reference)
CT	124 (15.8)	105 (14.7)	1.07 (0.80−1.42) 0.670	114/105	1.04 (0.78−1.39) 0.797
TT	1 (0.1)	11 (1.5)	0.07 (0.01−0.57) 0.013b	1/11	0.08 (0.01−0.65) 0.018
T allele	0.080	0.089

^aAdjusted for age, sex, diabetes status, smoking status, and family history of cancer.

^bOR (95% CI) = 0.09 (0.01−0.89), P=0.024 with further adjustment for body mass index.