Table 4.
Distribution of genotypes by diabetes status
| No. subjects (%) |
||||||||
|---|---|---|---|---|---|---|---|---|
| Genotype | Without diabetes |
With diabetes |
With diabetes > 2 years |
|||||
| Cases | Controls | Cases | Controls | P | Cases | Controls | P | |
| IGF1 16540 A>G | 0.107 | 0.062 | ||||||
| GG | 339 (55.1) | 343 (53.1) | 97 (55.4) | 46 (63.0) | 47 (49.5) | 37 (66.1) | ||
| AG & AA | 276 (44.9) | 303 (46.9) | 78 (46.6) | 27 (37.0) | 48 (50.5) | 19 (33.9) | ||
| IGF1 1830 C>T | 0.595 | 0.515 | ||||||
| TT | 297 (49.3) | 324 (50.9) | 83 (48.3) | 38 (54.3) | 42 (45.2) | 30 (55.6) | ||
| CT & CC | 305 (50.7) | 312 (49.1) | 89 (51.7) | 32 (45.7) | 51 (54.8) | 24 (44.4) | ||
| IGF1 − 177 G>C | 0.097 | 0.065 | ||||||
| GG | 497 (80.3) | 526 (81.2) | 132 (75.0) | 65 (89.0) | 68 (71.6) | 51 (91.1) | ||
| CG & CC | 122 (19.7) | 122 (18.8) | 44 (25.0) | 8 (11.0)a | 27 (28.4) | 5 (8.9) | ||
| IGF2 1280 A>G | 0.363 | 0.901 | ||||||
| GG | 231 (37.7) | 256 (39.9) | 67 (40.1) | 24 (34.3) | 38 (41.3) | 22 (40.7) | ||
| AG & AA | 382 (62.3) | 386 (60.1) | 100 (59.9) | 46 (65.7) | 54 (58.7) | 32 (59.3) | ||
| IGF2 −69 C>T | 0.847 | 0.441 | ||||||
| CC | 511 (83.1) | 534 (82.7) | 148 (84.6) | 61 (83.6) | 80 (84.2) | 44 (78.6) | ||
| CT & TT | 104 (16.9) | 112 (17.3) | 27 (15.4) | 12 (16.4) | 15 (15.8) | 12 (21.4) | ||
| IGF2 −233 C>T | 0.769 | 0.533 | ||||||
| CC | 515 (83.7) | 535 (83.6) | 146 (85.4) | 62 (84.9) | 78 (83.9) | 45 (80.4) | ||
| CT & TT | 100 (16.3) | 105 (16.4) | 25 (14.6) | 11 (15.1) | 15 (16.1) | 11 (19.6) | ||
a
P values are from χ2-test for comparison of genotype distributions between diabetic and non-diabetic controls.
bP values are from χ2-test for comparison of genotype distributions between non-diabetics and diabetics with >2 years of duration among controls.
cP = 0.013 and dP=0.052 from χ2-test for comparison of genotype distributions between cases and controls. All other P values are >0.05.