. Author manuscript; available in PMC: 2009 Dec 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3467–3473. doi: 10.1158/1055-9965.EPI-08-0514

Table 5.

Joint Effect of IGF1 genotype with diabetes in on risk of pancreatic cancer

Genotype		All subjects					Subjects with history of ≥ 2 years of diabetes mellitus
Genotype	Diabetes status	No. cases/no. controls	AOR (95% CI)^a	P	AOR (95% CI)^b		No. cases/no. controls	AOR (95% CI)^a		AOR (95% CI)^b
−16540 A>G
GG	No	339/343	1.00		1.00		339/343	1.00		1.00
AG&AA	No	276/303	0.91 (0.73−1.15)	0.433	1.02 (0.77−1.38)	0.859	276/303	0.91 (0.73−1.15)	0.438	1.03 (0.76−1.38)	0.849
GG	Yes	97/46	2.07 (1.41−3.05)	<0.001	2.13 (1.29−3.52)	0.003	47/37	1.22 (0.77−1.94)	0.397	1.00 (0.55−1.81)	0.996
AG&AA	Yes	78/27	2.86 (1.79−4.57)	<0.001	2.44 (1.39−4.29)	0.002	48/19	2.52 (1.44−4.41)	0.001	1.86 (0.94−3.68)	0.073
1830 C>T
TT	No	297/324	1.00		1.00		297/324	1.00		1.00
CC&CT	No	305/312	1.06 (0.84−1.33)	0.627	1.17 (0.87−1.57)	0.300	305/312	1.05 (0.84−1.32)	0.625	1.17 (0.87−1.58)	0.297
TT	Yes	83/38	2.32 (1.52−3.53)	<0.001	2.22 (1.29−3.81)	0.004	42/30	1.45 (0.88−2.39)	0.148	1.09 (0.57−2.05)	0.803
CC&CT	Yes	89/32	2.94 (1.88−4.48)	<0.001	2.52 (1.49−4.27)	0.001	51/24	2.26 (1.35−3.80)	0.002	1.71 (0.91−3.22)	0.097
−177 G>C
GG	No	497/526	1.00^c		1.00		497/526	1.00		1.00
CC&CG	No	122/122	1.07 (0.81−1.42)	0.628	1.19 (0.82−1.73)	0.358	122/122	1.07 (0.81−1.42)	0.627	1.19 (0.82−1.73)	0.355
GG	Yes	132/65	2.12 (1.53−2.93)	<0.001	2.00 (1.32−3.03)	0.001	68/51	1.38 (0.93−2.03)	0.109	1.10 (0.67−1.82)	0.705
CC&CG	Yes	44/8	5.69 (2.63−12.3)	<0.001	4.77 (1.91−11.9)	0.001	27/5	5.50 (2.09−14.5)	0.001	3.05 (1.07−8.70)	0.037

Odds ratio and 95% confidence interval adjusted for sex, age, family history of cancer, and smoking status.

Odds ratio and 95% confidence interval adjusted for sex, age, family history of cancer, smoking status, and BMI.

P for the interaction term of genotype and diabetes is 0.037.