Table 3.
Association of At-Goal A1C and Patient Reported Outcomes
| Characteristic | N | Patients At Goal | Patients Not At Goal | p-value& |
| Self-reported hypoglycemic episodes | ||||
| Patients with Hypoglycemic Symptoms (%) | 114 | 27.5% | 27.7% | 0.968 |
| Patients without Hypoglycemic Symptoms (%) | 299 | 72.5% | 72.3% | |
| Symptom Severity | ||||
| None (%) | 299 | 72.5% | 72.4% | 0.663 |
| †Mild resulting into no or little interruption in activities (%) | 76 | 19.7% | 18.0% | |
| †Moderate resulting into interruption in daily activities (%) | 28 | 7.8% | 6.4% | |
| *†Severe requiring some kind of medical or non-medical assistance (%) | 10 | 0% | 3.2% | |
| EQ VAS Score (mean ± std) | 414 | 77.0 ± 16.5 | 76.7 ± 15.5 | 0.854 |
| Adherence & Barriers to Adherence | ||||
| Always taking EXACTLY as prescribed (%) | 221 | 62.1% | 50.7% | 0.049 |
| Never UNSURE about instructions (%) | 323 | 80.6% | 77.7% | 0.534 |
| Never UNABLE to follow plans (%) | 313 | 82.5% | 73.8% | 0.072 |
| Never BOTHERED by side effects (%) | 266 | 73.8% | 61.5% | 0.024 |
| Never PROBLEMS getting Rx filled (%) | 379 | 95.2% | 91.5% | 0.230 |
| Satisfaction with Treatment | ||||
| Effectiveness (mean ± std) | 406 | 71.1 ± 16.3 | 65.9 ± 15.0 | 0.003 |
| Side Effects (mean ± std) | 410 | 92.7 ± 14.9 | 90.1 ± 17.0 | 0.174 |
| Convenience (mean ± std) | 412 | 67.3 ± 20.6 | 67.3 ± 17.8 | 0.986 |
| Global Satisfaction (mean ± std) | 113 | 75.5 ± 15.4 | 70.8 ± 16.3 | 0.012 |
% are based on column.
‡ Based on the Chi-square test of the null hypothesis of no association between patient reported experience of hypoglycemia and treatment adherence and barriers to adherence.
&Based on the Wald test of the null joint hypothesis of no association of the severity symptoms with adequate glycemic control (i.e. all coefficients are equal to zero).
¶ Based on the t-test of the null hypothesis of no association between patient reported experience of hypoglycemia and specified characteristics * Reference category
† {Mild: Little or no interruption of activities, and didn't feel the need of assistance to manage symptoms, Moderate: Some interruption of activities, but didn't feel the need of assistance to manage symptoms, Severe: The severe symptoms group is a consolidation of the 'severe' and 'very severe' symptoms that were respectively defined as: Felt that you needed assistance of others to manage symptoms (for example, to bring you food or drink), and needed medical attention (for example, called an ambulance, visited an emergency room or hospital, or saw a doctor or nurse)}.