Table 2.
MRS Ratios of the Posterior Cingulate Gyrus across Study Groups
| MRS | Controls | Mild AD | PDD | Controls | Controls | Mild AD |
|---|---|---|---|---|---|---|
| Ratio | N = 61 | N = 22 | N = 12 | vs. | vs. | vs. |
| Mean (SD) | Mean (SD) | Mean (SD) | Mild AD | PDD | PDD | |
| Cramer-Rao | Cramer-Rao | Cramer-Rao | p (Effect | p (Effect | p (Effect | |
| Bounds | Bounds | Bounds | Size)* | Size)* | Size)* | |
| NAA/Cr† | 1.353 (0.120) | 1.257 (0.190) | 1.243 (0.088) | 0.026 (0.67) | 0.014 (1.09) | 0.458 (0.11) |
| .069 | .075 | .070 | ||||
| Cho/Cr | 0.648 (0.051) | 0.683 (0.086) | 0.648 (0.059) | 0.016 (0.47) | 0.881 (0.00) | 0.127 (0.10) |
| .044 | .054 | .050 | ||||
| mI/Cr | 0.910 (0.099) | 1.025 (0.172) | 0.982 (0.147) | 0.001 (0.89) | 0.470 (0.63) | 0.053 (0.24) |
| .067 | .074 | .069 | ||||
| Glu/Cr | 0.540 (0.075) | 0.529 (0.098) | 0.448 (0.085) | 0.565 (0.12) | 0.006 (1.09) | 0.004 (0.81) |
| .085 | .105 | .089 |
*
All effects adjusted for group differences on age or gender
†
NAA = N-acetylaspartate; Cr = creatine; Cho = choline containing compounds; mI - myo-Inositol; Glu = glutamate