Table 2.
KEGG pathway enrichment for HHCV
| KEGG name | CORE | E1 | E2 | NS3 | NS5A | NS5B |
|---|---|---|---|---|---|---|
| Cell–cell and cell–ECM interactions | ||||||
| Adherens junction | 5 | 6 (5) | ||||
| Cell communication | 6 (2) | 8 (8) | ||||
| Cell adhesion molecules (CAMs) | 3 (1) | |||||
| ECM–receptor interaction | 2 (1) | 6 (6) | ||||
| Focal adhesion | 10 (9) | 8 (2) | ||||
| Gap junction | 4 | |||||
| Tight junction | 2 | |||||
| Signalling pathways | ||||||
| TGFβ signalling pathway | 4 | |||||
| Jak-STAT signalling pathway | 6 | 3 | ||||
| Adipocytokine signalling pathway | 5 | |||||
| MAPK signalling pathway | 3(2) | |||||
| Phosphatidylinositol signalling system | 2 | 4 | ||||
| Wnt signalling pathway | 7 (3) | |||||
| Insulin signalling pathway | 3 | |||||
| B cell receptor receptor signalling pathway | 3 | |||||
| T cell receptor signalling pathway | 5 | |||||
Over-represented KEGG pathways were identified after multiple testing adjustments (adjusted P-value <5 × 10−2) and are listed by viral protein. For each pathway, number of HHCV is given, with the relative contribution of IMAP Y2H dataset in brackets. Shaded entries denote discussed pathways.