Table 1. Clinical characteristics, results of Snail and E-cadherin immunohistochemistry in 26 patients with ACC.
| Patient no. | Age | Sex | Histo | Size/Site | TNM | Ki-67 (%) | Scoring (W/VS/H) | E-cad IHC | Snail IHC | Follow up (months) | Distant metastases |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 57 | F | ACC | 200/l | III | 10 | 4/9/3.11 | − | ++ | NED (132) | N |
| 2 | 43 | F | ACC | 170/r | IV | 10 | 6/20/4.52 | − | ++ | DOD (14) | Y |
| 3 | 42 | M | ACC | 170/l | III | 10 | 5/18/3.13 | − | ++ | DOD (41) | Y |
| 4 | 53 | F | ACC | 100/l | III | 20 | 4/23.5/1.68 | − | ++ | DOD (17) | Y |
| 5 | 73 | F | ACC | 85/l | III | 1 | 5/12.3/1.89 | − | ++ | DURC (15) | N |
| 6 | 39 | F | ACC | 130/l | II | 10 | 2/5.7/1.69 | − | ++ | NED (72) | N |
| 7 | 37 | F | ACC | 90/l | III | 30 | 5/14.7/4.5 | − | ++ | DOD (42) | Y |
| 8 | 46 | F | ACC | 30/r | I | 10 | 4/9/2.61 | + | ++ | NED (40) | N |
| 9 | 49 | F | ACC | 70/l | II | 2 | 5/13.7/2 | − | ++ | NED (14) | N |
| 10 | 72 | F | ACC | 60/l | IV | 5 | 7/17.8/3.29 | − | ++ | DOD (14) | Y |
| 11 | 26 | M | ACC | 80/r | IV | 20 | ND | − | ++ | DOD (12) | Y |
| 12 | 34 | F | ACC | 120/r | III | 1 | 4/14.7/2.29 | − | + | DOD (22) | Y |
| 13 | 46 | M | ACC | 105/r | IV | 10 | 6/24.2/3.92 | − | + | DOD (7) | Y |
| 14 | 50 | F | ACC | 95/r | II | 5 | 5/9//4.13 | − | + | DOD (17) | Y |
| 15 | 41 | M | ACC | 210/l | II | 1 | 7/17.8/3.89 | − | + | DOD (11) | Y |
| 16 | 69 | M | ACC | 100/r | IV | 30 | 7/20.1/3.52 | − | + | AWD (5) | Y |
| 17 | 72 | M | ACC | 95/l | II | 5 | 4/10.4/2.6 | − | + | NED (5) | N |
| 18 | 24 | F | ACC | 75/r | II | 3 | 3/8/1.31 | + | − | NED (6) | N |
| 19 | 22 | F | ACC | 120/r | II | 1 | 5/21.1/2.83 | − | − | DURC (15) | N |
| 20 | 15 | M | ACC | 120/l | II | 2 | 5/19.1/2.6 | − | − | DOD (23) | Y |
| 21 | 72 | M | ACC | 110/r | II | 5 | 6/26.8/4.52 | − | − | AWD (82) | Y |
| 22 | 83 | F | ACC | 120/l | II | 30 | 8/26.8/3.89 | + | − | NED (50) | N |
| 23 | 58 | F | ACC | 60/r | II | 2 | 4/12.1/2..23 | − | − | NED (34) | N |
| 24 | 55 | F | ACC | 150/l | IV | 20 | 8/26.8/5.21 | − | − | AWD (12) | Y |
| 25 | 50 | F | ACC | 100/l | II | 2 | 4/8/1.68 | − | − | R(108), NED(153) | N |
| 26 | 43 | F | ACC | 70/l | II | 20 | 2/5.7/1.69 | − | − | NED (6) | N |
ACC=Adrenocortical Carcinoma; AWD=Alive with disease; DURC=death of unrelated cause; DOD=Dead of disease; E-cad=E-cadherin expression; H=Hough; IHC=Immunohistochemistry; NED=No evidence for disease; VS=van Slooten; W=Weiss.