Table 2. Clinical parameters selected with stepwise backward selection in multivariate Cox-regression analyses including signature 2.

	Hazard ratio (95% CI)	P-value
Miller
Tumor size	3.3 (1.7–6.6)	0.0006
LNSa	2.8 (1.6–5.0)	0.0003
Proliferationb	3.4 (1.4–8.2)	0.0052
Wang
Proliferationb	2.6 (1.5–4.4)	0.0004
Van de Vijver
Age	0.95 (0.91–0.99)	0.0096
Tumour sizec	1.5 (0.93–2.5)	0.0962
Elston grade	2.2 (1.4–3.4)	0.0003
Proliferationb	21 (1.8–234)	0.0148
Zhao
Performance status	1.3 (1.1–1.6)	0.0069
Grade	1.5 (1.0–2.1)	0.0260
Stage	3.3 (2.5–4.4)	< 0.0001
Beer
Age	1.0 (1.0–1.1)	0.0338
Stage	2.3 (1.5–3.5)	0.0002
Proliferationb	1.8 (0.9–3.5)	0.0884

^aLNS=lymph-node status.

^bProliferation: proliferation signature 2.

^cCategories: ⩽2 or >2 cm.