Table 1. Toxicity associated with a combination of platinum and taxane.
|
Chemotherapy dose
|
Grades 3–4 toxicity (%)
|
|||||
|---|---|---|---|---|---|---|
| Research group | Platinum | Taxane | No. of patients | NP | FNP | Reference |
| A combination of carboplatin and paclitaxel | ||||||
| Japan | 6 (AUC) | 200 (mg m−2) | 145 | 88 | 16 | Ohe et al (2007) |
| Greece | 6 (AUC) | 200 (mg m−2) | 252 | 15 | 0 | Kosmidis et al (2002) |
| EU | 6 (AUC) | 200 (mg m−2) | 309 | 51 | 4 | Rosell et al (2002) |
| ECOG | 6 (AUC) | 225 (mg m−2) | 290 | 63 | 4 | Schiller et al (2002) |
| SWOG | 6 (AUC) | 225 (mg m−2) | 206 | 57 | 2 | Kelly et al (2001) |
| SWOG | 6 (AUC) | 225 (mg m−2) | 182 | — | 3 | Gandara et al (2004) |
| USA | 6 (AUC) | 225 (mg m−2) | 190 | 65 | — | Belani et al (2005) |
| USA | 6 (AUC) | 225 (mg m−2) | 345 | 6 | — | Herbst et al (2004) |
| A combination of cisplatin and docetaxel | ||||||
| Japan | 80 (mg m−2) | 60 (mg m−2) | 151 | 74 | 2 | Ohe et al (2007) |
| ECOG | 75 (mg m−2) | 75 (mg m−2) | 289 | 69 | 11 | Schiller et al (2002) |
| USA | 75 (mg m−2) | 75 (mg m−2) | 408 | 75 | 5 | Fossella et al (2003) |
NP, neutropenia; FNP, febrile neutropenia.