Table 2. Toxicity associated with a combination of cisplatin and vinorelbine.
|
Chemotherapy dose (mg m−2) |
Grades 3–4 toxicity (%)
|
|||||
|---|---|---|---|---|---|---|
| Research group | Cisplatin | Vinorelbine | No. of patients | NP | FNP | Reference |
| Japan | 80 (day 1) | 25 (days 1, 8) | 145 | 88 | 18 | Ohe et al (2007) |
| Greece | 80 (day 8) | 30 (days 1, 8) | 204 | 37 | 11 | Georgoulias et al (2005) |
| France | 100 (day 1) | 30 (weekly) | 156 | 83 | 22 | Pujol et al (2005) |
| EU | 120 (day 1) | 30 (weekly) | 206 | 79 | 4 | Le Chevalier et al (1994) |
| SWOG | 100 (day 1) | 25 (weekly) | 202 | 76 | 1 | Kelly et al (2001) |
| USA | 100 (day 1) | 25 (weekly) | 404 | 79 | 5 | Fossella et al (2003) |
NP, neutropenia; FNP, febrile neutropenia.