Table 3. Incidence of EGFR mutations in surgically resected specimens.
|
All cases
|
Adenocarcinoma
|
Non-smokers
|
|||||
|---|---|---|---|---|---|---|---|
| Total | Mutation | Total | Mutation | Total | Mutation | ||
| Author | Country | N | N (%) | N | N (%) | N | N (%) |
| Western areas | |||||||
| Shigematsu | USA | 80 | 11 (14) | 44 | 11 (25) | 26 | 7 (27) |
| Pao | USA | 96 | 11 (11) | 72 | 11 (15) | 15 | 7 (47) |
| Yang | USA | 219 | 26 (12) | 164 | 25 (15) | 34 | 12 (35) |
| Marchetti | Italy | 860 | 39 (5) | 375 | 39 (10) | 103a | 23 (22) |
| Subtotal | 1255 | 87 (7) | 655 | 86 (13) | 75 | 26 (35) | |
| Asian areas | |||||||
| Shigematsu | Japan | 263 | 71 (27) | 154 | 67 (44) | 78 | 47 (60) |
| Kosaka | Japan | 277 | 111 (40) | 224 | 110 (49) | 112a | 76 (68) |
| Tokumo | Japan | 120 | 38 (32) | 82 | 37 (45) | 36 | 25 (69) |
| Sasaki | Japan | 95 | 35 (37) | 71 | 32 (45) | 36 | 25 (69) |
| Shigematsu | Taiwan | 93 | 32 (34) | 55 | 31 (56) | 55 | 27 (49) |
| Qin | China | 41 | 10 (24) | 17 | 7 (41) | 21 | 6 (29) |
| Soung | Korea | 153 | 30 (20) | 69 | 26 (38) | 54 | 25 (46) |
| Shigematsu | Others | 361 | 107 (30) | 214 | 102 (48) | 135 | 76 (56) |
| Subtotal | 1403 | 434 (31) | 886 | 412 (47) | 415 | 231 (56) | |
| Other areas | |||||||
| Shigematsu | Australia | 83 | 6 (7) | 36 | 5 (14) | 7 | 4 (57) |
| Shigematsu | Others | 158 | 13 (8) | 75 | 12 (16) | 31 | 9 (29) |
| Subtotal | 241 | 19 (8) | 111 | 17 (15) | 38 | 13 (34) | |
| Toatl | 2899 | 540 (19) | 1652 | 515 (31) | 528 | 270 (51) | |
a
Including only patients with adenocarcinoma histology.