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. 2008 Nov 11;99(11):1832–1841. doi: 10.1038/sj.bjc.6604763

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Copyright © 2008 Cancer Research UK

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Induction of apoptosis by γ-T3 treatment. (A) Cell cycle analysis by flow cytometry. Control cells and treated cells incubated with γ-T3 at IC₅₀ for 24-h were subjected to flow cytometry analysis. Note that the sub-G1 population appears after treatment. (B) IC₅₀ time-dependent and 24-h dose-dependent activation (in hrs and μM respectively) of the pro-apoptosis pathway in PC-3. Note that γ-T3 induces activation of the critical molecules (cleaved caspase 3, 7, 8, 9, PARP) and modulate the ratio between the amounts of bcl-2 and bax in a cell dose- and time-dependent fashion. (C) IC₅₀ γ-T3 activates pro-apoptotic genes and suppresses pro-survival genes expression on LNCaP and PC-3 but not on non-tumorigenic prostate epithelial cells (PZ-HPV) for 24-h incubation period.