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. Author manuscript; available in PMC: 2008 Dec 11.
Published in final edited form as: J Chem Theory Comput. 2006;2(4):1057–1069. doi: 10.1021/ct0600060

Figure 2.

Figure 2

Schematic representation of the proposed acid-base mechanism proposed by Andreeva et al. 10 for the proteolysis reactions catalyzed by aspartyl proteases. (a) The initial step before substrate binding. (b) The tetrahedral intermediate and its interactions with the key residues. The numbering scheme is for pepsins.