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. 2008 Dec 15;183(6):1129–1143. doi: 10.1083/jcb.200807020

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© 2008 Harris and Tepass

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — crb and shg enhance the Cdc42-DN phenotype. Quantification of ventral cuticle defects in wild-type; Cdc42-DN; Cdc42-DN, crb/+; Cdc42-DN, shg/+; and Cdc42-DN, Notch/+ embryos. Embryo collections of double-mutant genotypes contained a predicted 50% of double mutants and 50% of Cdc42-DN embryos. (A) The number of intact abdominal denticle belts is presented as mean ± SEM (error bars). For Cdc42-DN, crb/+ and Cdc42-DN, shg/+ embryos, the difference in the mean number of intact belts relative to Cdc42-DN embryos is statistically significant (P < 0.001). For Cdc42-DN, Notch/+ embryos, there is no significant difference relative to Cdc42-DN embryos. (B) Distribution of ventral cuticle phenotypes in a population of Cdc42-DN embryos. (C) Distribution of ventral cuticle phenotypes in a population in which 50% of embryos are predicted to be Cdc42-DN and 50% are predicted to be Cdc42-DN, crb^11a22/+. (C′) Ventral cuticle of a Cdc42-DN embryo. Arrows indicate holes in the ventral surface. (C′′) Ventral cuticle of an embryo from a Cdc42-DN, crb/+ population with severely enhanced ventral defects (indicated by bracket). (D) Distribution of ventral cuticle phenotypes in a population in which 50% of embryos are predicted to be Cdc42-DN and 50% are predicted to be Cdc42-DN, shg^R69/+. (E) Distribution of ventral cuticle phenotypes in a population in which 50% of embryos are predicted to be Cdc42-DN and 50% are predicted to be Cdc42-DN, N^55e11/+. Bar, 100 μm.