Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A model for the functions of miR-133a in the heart. SRF and MEF2 activate miR-133a expression, which directly or indirectly represses genes involved in many aspects of heart development and function, including sarcomeric structures, cell proliferation, apoptosis, and the smooth muscle gene program. miR-133a directly targets SRF, which provides a negative feedback loop to precisely modulate SRF activity.
