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. 2008 Dec 1;22(23):3255–3267. doi: 10.1101/gad.1723908

Figure 5.

Figure 5.

Sf1-Cre;Pdgfrαfl−/− testes and ovaries recover fertility. (A) At 6 wk of age, testosterone was low in most Sf1-Cre;Pdgfrαfl−/− testes (12 out of 16, or 75%, using the mean at 6 wk as a cutoff). However by 10 wk, higher testosterone levels were detected in most Sf1-Cre;Pdgfrαfl−/− testes (eight out of 14, or 54%). (B) By 10 wk, Sf1-Cre;Pdgfrαfl−/− testes appeared normal. (C) Pdgfrα expression did not increase in Sf1-Cre;Pdgfrαfl−/− testes over this period. (D) Pdgfrβ expression changed in Cre;Pdgfrαfl−/− testes over time and was observed to be higher in samples with high testosterone levels than in samples with low testosterone levels by 10 wk. (E) In the ovary, Pdgfrβ expression is close to wild type at 6 wk of age and increases by 10 wk of age. Wild-type samples are a pool of samples between 6 and 10 wk. Expression levels were normalized for each sample using Ubc.