. Author manuscript; available in PMC: 2009 Oct 1.

Published in final edited form as: Schizophr Res. 2008 Jul 11;105(1-3):188–196. doi: 10.1016/j.schres.2008.06.003

Table 3.

First-episode schizophrenia patients: Progression of moderate to severe negative symptom levels over time

	affective flattening		poverty of speech		avolition		anhedonia
Fixed effects:	est (se)	p-value^*	est (se)	p-value^*	est (se)	p-value^*	est (se)	p-value^*
Intercept	−0.441 (0.44)		−2.827 (0.77)		1.317 (0.40)		1.434 (0.48)
slope (0–30 days)	−0.012 (0.02)	0.453 0.696^#	0.029 (0.02)	0.149 0.148^#	−0.053 (0.02)	0.001 *<0.0005*^#	−0.016 (0.02)	0.331 0.007^#
slope (30-365 days)	0.008 (0.02)	0.634 0.724^#	−0.030 (0.02)	0.154 0.181^#	0.052 (0.02)	0.002 *< 0.0005*^#	0.018 (0.02)	0.297 0.011^#
Random effects:
σ_int	2.033 (0.68)	0.003	2.249 (0.73)	0.002	0.962 (0.56)	0.088	1.591 (0.62)	0.011
σ_slope	−0.010 (0.007)	0.094	−0.010 (0.005)	0.027	0.005 (0.004)	0.107	0.010 (0.005)	0.045
σ_intslope	0.006 (0.006)	0.340	−0.005 (0.004)	0.150	−0.001 (0.004)	0.742	0.0004 (0.004)	0.999

Significance of the random effects estimates is only approximate; estimates (σ) are the components of the variance attributed to subject level differences

for comparison, p-values of a continuous data linear mixed model with the same structure are given