Table 3.
Association of SREBP-2 gene polymorphisms between the AVN subgroup patients and controls
| Loci | Sub-group | Genotype | Allele 2 vs. 1 | Codominant Heterozy | Dominant | Recessive | |||||||
| 11 | 12 | 22 | MAF | (11 vs 12 vs 22)* | 12 + 22 vs. 11 | 22 vs. 11 + 12 | |||||||
| OR (95% CI) | P† | OR (95% CI) | P† | OR (95% CI) | P† | OR (95% CI) | P† | ||||||
| TT | CT | CC | |||||||||||
| IVS1+8408 T>C | Alc | 74 | 102 | 30 | 0.393 | 0.764 (0.581–1.004) |
0.054 | 0.759 (0.575–1.002) |
0.052 | 0.744 (0.494–1.121) |
0.157 | 0.629 (0.379–1.045) |
0.073 |
| (rs2267439) | Idio | 69 | 85 | 27 | 0.384 |
0.701 (0.532–0.923) |
0.011 |
0.695 (0.525–0.920) |
0.011 |
0.625 (0.417–0.937) |
0.023 | 0.617 (0.368–1.034) |
0.067 |
| Ster | 16 | 31 | 9 | 0.438 | 0.865 (0.560–1.335) |
0.511 | 0.860 (0.553–1.339) |
0.504 | 0.940 (0.479–1.844) |
0.857 | 0.677 (0.301–1.523) |
0.346 | |
| GG | GT | TT | |||||||||||
| IVS3-342 G>T | Alc | 115 | 74 | 16 | 0.259 | 1.017 (0.747–1.386) |
0.914 | 1.016 (0.751–1.375) |
0.916 | 1.021 (0.694–1.501) |
0.917 | 1.022 (0.495–2.109) |
0.954 |
| (rs2269657) | Idio | 94 | 73 | 14 | 0.279 | 1.159 (0.855–1.570) |
0.342 | 1.165 (0.855–1.589) |
0.333 | 1.153 (0.785–1.695) |
0.468 | 1.431 (0.675–3.030) |
0.350 |
| Ster | 32 | 20 | 2 | 0.222 | 0.951 (0.568–1.592) |
0.848 | 0.949 (0.561–1.604) |
0.845 | 0.989 (0.527–1.858) |
0.973 | 0.704 (0.150–3.297) |
0.656 | |
| GG | AG | AA | |||||||||||
| IVS11+414 G>A | Alc | 95 | 84 | 25 | 0.328 | 1.241 (0.925–1.665) |
0.150 | 1.244 (0.925–1.672) |
0.149 | 1.143 (0.779–1.678) |
0.493 |
2.037 (1.028–4.034) |
0.041 |
| (rs1052717) | Idio | 85 | 72 | 24 | 0.332 | 1.214 (0.910–1.621) |
0.188 | 1.214 (0.909–1.621) |
0.189 | 1.092 (0.747–1.598) |
0.649 |
1.998 (1.055–3.783) |
0.034 |
| Ster | 22 | 30 | 4 | 0.339 | 1.230 (0.778–1.945) |
0.376 | 1.258 (0.775–2.042) |
0.352 | 1.452 (0.782–2.695) |
0.237 | 0.966 (0.295–3.163) |
0.954 | |
| GG | AG | AA | |||||||||||
| IVS12-1667 G>A | Alc | 74 | 95 | 30 | 0.389 |
1.380 (1.036–1.837) |
0.027 |
1.382 (1.036–1.844) |
0.028 |
1.495 (1.007–2.220) |
0.046 | 1.575 (0.877–2.828) |
0.128 |
| (rs2267443) | Idio | 73 | 71 | 31 | 0.380 | 1.236 (0.930–1.642) |
0.144 | 1.226 (0.927–1.620) |
0.153 | 1.126 (0.759–1.669) |
0.556 |
1.763 (1.015–3.059) |
0.044 |
| Ster | 22 | 26 | 8 | 0.375 | 1.334 0.849–2.094) |
0.211 | 1.340 (0.849–2.114) |
0.209 | 1.408 (0.749–2.647) |
0.288 | 0.566 (0.637–3.852) |
0.328 | |
*11: homozygotes for the major allele, 12: heterozygotes and 22: homozygotes for the minor allele.
† Logistic regression analyses were used for calculating. bold: P value < 0.05