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Histogram depicting the relative amounts of Aβ40 and Aβ42 detected by ELISA. Notice the abundant amount of Aβ40 in the PSEN A431E, V261F, V261I and M146L. The amounts of Aβ40 and Aβ42 were almost equivalent in case F105L. PSEN = presenilin; SAD = Alzheimer's disease; ND = non-demented.
