Scheme 4.
Reagents and conditions: (a) CbzCl, NaH, THF, 0 °C (95%); (b) NaBH4, CH3OH, 0 °C (88%); (c) NH3, THF, 80 °C, sealed tube (68%); (d) 10% Pd/C, H2 (1 atm), THF, AcOH, 23 °C (73%).
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.