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Hyperthermia-induced EAD-mediated triggered beat and spontaneous TdP in the presence of combined IKr and IKs block (E-4031 and chromanol 293B).
A: Action potentials and ECG recorded from a wedge preparation perfused with 37°C (left) and 40°C (right) Tyrode’s solution and paced at a BCL of 1000 ms.
B: An ECG tracing of a spontaneous TdP observed when the coronary perfusate was warmed to 39°C.
