. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Circ Arrhythm Electrophysiol. 2008 Aug;1(3):202–208. doi: 10.1161/CIRCEP.107.691931

Table 1.

The effect of temperature on transmural dispersion of action potential duration (APD₉₀) recorded from isolated canine left ventricular tissue slices and arterially-perfused wedge preparations in the absence (control) and presence of E-4031 (1 μmol/L), chromanol 293B (293B, 30 μmol/L), or combination of these 2 agents. BCL = 2000 ms.

	Tissue Slices			Perfused Wedge

T°C	36°	38°	40°	36-37°	39-40°
Control	84±16	91±22	110±27^*	52±17	47±15
E-4031	332±63^∥	451±129^†^∥	654±180^‡^∥	61±22	58±27
293B	81±18	88±19	109±23^*	54±15	51±14
E-4031+293B	-	-	-	91±28^¶	173±61^§^#

p<0.05

^†

p<0.001

^‡

p<0.0005 vs. 36°C

^§

p<0.05 vs. 36-37°C.

^∥

p<0.0005

^¶

p<0.05

p<0.001 vs. control for the same temperature. N=6-12. Mean±SD.