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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2008 Aug;1(3):202–208. doi: 10.1161/CIRCEP.107.691931

TABLE 2.

Temperature-dependent incidence of early afterdepolarization activity (EAD) and Torsade de Pointes (TdP) in arterially-perfused wedge

t°C EAD activity TdP
Epi M Subepi M Subendo Endo
Control 36-37 0/10 0/10 0/10 0/10 0/10
39-40 0/10 0/10 0/10 0/10 0/10
E-4031 (1μ mo/L) 36-37 0/8 0/8 0/8 0/8 0/8
39-40 0/8 0/8 0/8 0/8 0/8
293B (30 μ mol/L) 36-37 0/6 0/6 0/6 0/6 0/6
39-40 0/6 0/6 0/6 0/6 0/6
E-4031+293B 36-37 4/12 4/12 3/12 2/12 3/12
39-40 8/12 9/12 4/12 1/12 6/12

Epi = epicardium; M Subepi = subepicardial M cell region; M Subendo = subendocardial M cell region; Endo = endocardium; 293B = chromanol 293B.