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Polar buried residues in interfaces are as conserved as all other residues. Polar residues include Asp, Glu, Lys, Arg, Ser, Thr, Asn, and Gln. All other residues are classified as the remainder. The median dN for each dataset is shown.
| Structural subset | Surface | Core | Surface interface | Buried interface |
|---|---|---|---|---|
| dN polars | 0.434 | 0.305 | 0.322 | 0.219 |
| dN remainder | 0.311 | 0.209 | 0.260 | 0.184 |
| P (Wilcoxan) | 2.4e-7 | 1.9e-6 | 0.002 | 0.730 |
