Table 2.
Age specific incidence of cardiovascular disease by subtype in participants of Physicians’ Health Study
| Variables | No of events | Incidence per 100 000 person years (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|
| 40-49 years | 50-59 years | 60-69 years | 70-79 years | 80-89 years | 90-99 years | Overall | ||
| Person years of follow-up | — | 46 901 | 125 436 | 160 772 | 99 028 | 32 142 | 3312 | 467 591 |
| Confirmed end points: | ||||||||
| Major cardiovascular disease* | 3252 | 104.5 (77.29 to 138.12 | 333.2 (302.05 to 366.76) | 579.7 (543.08 to 618.16) | 1107.8 (1043.21 to 1175.31) | 2031.6 (1878.80 to 2193.63) | 3110.4 (2538.72 to 3772.3) | 695.5 (671.76 to 719.82) |
| Non-fatal myocardial infarction | 1430 | 68.2 (46.64 to 96.27) | 209.9 (185.28 to 236.73) | 311.4 (284.81 to 339.71) | 414.7 (376.16 to 456.11) | 545.4 (470.24 to 629.22) | 434.5 (248.38 to 705.69) | 300.6 (285.26 to 316.63) |
| Non-fatal stroke | 1210 | 27.7 (14.74 to 47.33) | 84.5 (69.25 to 102.11) | 184.6 (164.44 to 206.49) | 454.8 (414.77 to 497.63) | 807.1 (715.31 to 907.36) | 849 (576.84 to 1205.03) | 251.3 (237.39 to 265.92) |
| Death from cardiovascular disease | 612 | 8.5 (2.31 to 21.79) | 37.0 (27.18 to 49.19) | 72.4 (60.34 to 86.52) | 184.9 (160.08 to 212.43) | 497.3 (428.24 to 574.39) | 1,373.6 (1037.55 to 1783.72) | 124.9 (115.18 to 135.17) |
| Self reported end points: | ||||||||
| Angina | 3521 | 227.2 (185.99 to 274.76) | 496.9 (502.58 to 589.81) | 906.0 (858.95 to 954.87) | 1,207.8 (1137.51 to 1281.40) | 1,020.9 (907.90 to 1144.08) | 513.1 (293.26 to 833.21) | 788.5 (762.66 to 814.98) |
| CABG or PTCA | 2197 | 81.0 (57.32 to 111.18) | 277.7 (249.25 to 308.41) | 536.8 (501.54 to 574.00) | 773.9 (719.87 to 830.80) | 552.0 (474.71 to 638.25) | 242.6 (110.91 to 460.45) | 470.2 (450.78 to 490.31) |
| All cardiovascular disease† | 4517 | 246.9 (203.88 to 296.41) | 571.1 (529.47 to 615.10) | 1038.7 (987.65 to 1091.65) | 1719.7 (1633.04 to 1809.86) | 2338.9 2156.09 to 2533.13) | 2827.1 (2219.97 to 3549.20) | 1044.8 (1014.58 to 1075.75) |
CABG=coronary artery bypass grafting; PTCA=percutaneous coronary angioplasty.
*Confirmed end points of myocardial infarction, stroke, or death from cardiovascular disease.
†Self reported angina or revascularisation procedures are included as cardiovascular disease defining events as well as confirmed end points of myocardial infarction, stroke, or death from cardiovascular disease.