Table 3.
Age specific incidence of overall and specific cancers in participants of Physicians’ Health Study
| Variables | No (%) of cancers | Incidence per 100 000 person years (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|
| 40-49 years | 50-59 years | 60-69 years | 70-79 years | 80-89 years | 90-99 years | Overall | ||
| Person years of follow-up | — | 46 838 | 125 132 | 157 849 | 92 701 | 29 076 | 2960 | 454 557 |
| Cancer subtype: | ||||||||
| All cancers | 5400 (100.0) | 160.1 (125.95 to 200.72) | 431.5 (395.90 to 469.51) | 1242.3 (1187.96 to 1298.53) | 2172.6 (2078.73 to 2269.59) | 2555.3 (2374.86 to 2745.82) | 2263.5 (1754.20 to 2874.57) | 1188.0 (1156.53 to 1220.05) |
| Prostate | 2548 (47.2) | 4.3 (0.52 to 15.44) | 133.7 (114.15 to 155.53) | 641.2 (602.21 to 681.97) | 1152.6 (1084.33 to 1224.04) | 1008.7 (896.08 to 1131.47) | 545.2 (311.64 to 885.45) | 562.3 (540.70 to 584.57) |
| Colorectal | 554 (10.3) | 15.0 (6.01 to 30.81) | 52.9 (40.87 to 67.23) | 114.0 (97.95 to 132.03) | 209.2 (180.64 to 240.95) | 351.2 (286.08 to 426.78) | 307.1 (140.41 to 582.90) | 122.5 (112.54 to 133.18) |
| Lymphoma | 354 (6.6) | 17.1 (7.38 to 33.68) | 35.2 (25.60 to 47.30) | 75.2 (62.24 to 90.05) | 126.4 (104.47 to 151.64) | 226.2 (174.57 to 288.28) | 102.5 (21.13 to 299.43) | 78.3 (70.37 to 86.91) |
| Lung | 340 (6.3) | 2.1 (0.05 to 11.90) | 20.0 (12.96 to 29.55) | 72.0 (59.35 to 86.58) | 154.7 (130.34 to 182.39) | 181.0 (135.17 to 237.35) | 239.0 (96.06 to 492.23) | 75.2 (67.43 to 83.65) |
| Melanoma | 305 (5.7) | 49.1 (31.15 to 73.72) | 38.4 (28.34 to 50.95) | 66.9 (54.73 to 81.00) | 95.9 (76.94 to 118.19) | 135.8 (96.55 to 185.60) | 68.3 (8.27 to 246.83) | 67.5 (60.12 to 75.49) |
| Urinary tract* | 300 (5.6 ) | 15.0 (6.01 to 30.81) | 23.2 (15.55 to 33.35) | 68.18 (55.88 to 82.40) | 123.16 (101.50 to 148.07) | 142.73 (102.43 to 193.63) | 102.46 (21.13 to 299.43) | 66.37 (59.07 to 74.32) |
| Other gastrointestinal† | 286 (5.3) | 8.6 (2.33 to 21.88) | 23.2 (15.55 to 33.35) | 49.1 (38.73 to 61.33) | 119.9 (98.54 to 114.51) | 205.3 (156.30 to 264.86) | 238.9 (96.06 to 492.23) | 63.3 (56.15 to 71.05) |
| Leukaemia | 181 (3.4) | 2.1 (0.05 to 11.91) | 23.2 (15.55 to 33.35) | 42.1 (32.53 to 53.52) | 56.7 (42.34 to 74.35) | 101.0 (67.63 to 145.02) | 136.6 (37.22 to 349.71) | 40.1 (34.43 to 46.33) |
| Head and neck | 116 (2.2) | 8.6 (2.33 to 21.88) | 13.6 (7.83 to 21.80) | 31.2 (23.11 to 41.29) | 33.8 (22.97 to 47.98) | 45.3 (24.11 to 77.43) | 68.3 (8.27 to 246.79) | 25.7 (21.21 to 30.79) |
| Unknown | 101 (1.9) | 2.1 (0.05 to 11.91) | 8.8 (4.40 to 15.76) | 18.5 (12.38 to 26.55) | 36.0 (24.76 to 50.53) | 73.1 (45.27 to 111.79) | 204.8 (75.16 to 445.80) | 22.4 (18.20 to 27.16) |
| Brain | 97 (1.8) | 2.1 (0.05 to 11.91) | 18.4 (11.68 to 27.34) | 23.6 (16.61 to 32.51) | 22.9 (14.18 to 35.00) | 45.3 (24.11 to 77.43) | 68.3 (8.27 to 246.79) | 21.5 (17.41 to 26.19) |
| Other | 218 (4.0) | 34.2 (19.54 to 55.51) | 41.6 (31.10 to 54.60) | 45.9 (35.90 to 57.79) | 57.8 (43.28 to 75.58) | 66.2 (39.84 to 103.33) | 204.8 (75.16 to 445.80) | 48.23 (42.04 to 55.08) |
*Includes urinary tract and genital tumours.
†Includes oesophagus, stomach, pancreas, and hepatobiliary cancers.