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NHEJ phenotype of Xrs2 FHA domain mutants
|
YKU80
|
yku80Δ605–629
|
|||
|---|---|---|---|---|
| XRS2 | Total | HO(+2) | Total | HO(+2) |
| wt | 1a | 1 | 2 | 8 |
| Δ∷kanMX4 | 8 | 100 | 125 | ∞ |
| ΔFHA | 1 | 1.7 | 30 | >1000 |
| R32A | 1 | 1.8 | 22 | >1000 |
| S47A | 1 | 2 | 27 | >1000 |
| R48A | 1 | 1.6 | 24 | >1000 |
| H50A | 1 | 1 | 5 | 37 |
| K75A | 1 | 1.2 | 14 | 60 |
wt, wild type.
Numbers indicate the average fold decrease as compared to YKU80 XRS2 yeast for total and HO(+2) NHEJ in the suicide deletion assay.
