. Author manuscript; available in PMC: 2009 Jun 1.

Published in final edited form as: Food Chem Toxicol. 2008 Feb 5;46(6):2062–2073. doi: 10.1016/j.fct.2008.01.047

Table 5.

Effects on Hepatic Glutathione Status

Genotype	Dietary Vitamin E	Treatment	GSH^a,^b	GSSG	GSH/GSSG^a,^b
p50+/+	10 mg/kg	Control	12.15 ± 0.42	0.84 ± 0.11	15.34 ± 2.28
		CIP	12.11 ± 1.03	0.80 ± 0.08	15.33 ± 1.16
	250 mg/kg	Control	14.43 ± 0.26	0.69 ± 0.11	23.06 ± 4.13
		CIP	13.00 ± 0.42	0.77 ± 0.22	19.14 ± 4.07
p50−/−	10 mg/kg	Control	11.41 ± 0.28	0.75 ± 0.07	15.63 ± 1.48
		CIP	10.94 ± 0.49	1.35 ± 0.35	10.79 ± 2.66
	250 mg/kg	Control	12.07 ± 0.63	0.74 ± 0.04	16.51 ± 1.28
		CIP	11.99 ± 0.27	0.82 ± 0.07	15.16 ± 1.72

GSH and GSSG are expressed as mean (µmol/g liver) ± SEM with n = 3–5.

p50−/− mice are significantly different from wild-type mice based on ANOVA (p<0.05).

Mice fed high vitamin E are significantly different from mice fed low dietary vitamin E based on ANOVA (p<0.05).