Table 6.
Effects of ciprofibrate (CIP) and dietary vitamin E on cyclin mRNA concentrations in livers from female p50+/+ and p50−/− mice
| Genotype | Dietary Vitamin E | Treatment | Cyclin A2 | Cyclin C | Cyclin D1 | Cyclin D2b | Cyclin D3 | Cyclin B2b |
|---|---|---|---|---|---|---|---|---|
| p50+/+ | 10 mg/kg | Control | 0.85 ± 0.04 | 2.24 ± 0.20 | 8.39 ± 0.84 | 2.91 ± 0.45 | 3.44 ± 0.21 | 2.58 ± 0.19 |
| CIP | 0.77 ± 0.06 | 1.93 ± 0.06 | 13.34 ± 2.11a | 3.19 ± 0.32 | 4.71 ± 0.20a | 3.10 ± 0.16 | ||
| 250 mg/kg | Control | 0.86 ± 0.01 | 2.48 ± 0.15 | 11.56 ± 2.42 | 3.36 ± 0.43 | 3.80 ± 0.15 | 2.82 ± 0.16 | |
| CIP | 0.91 ± 0.04 | 2.02 ± 0.05 | 14.50 ± 1.33a | 3.76 ± 0.37 | 4.50 ± 0.17 | 3.48 ± 0.08 | ||
| p50−/− | 10 mg/kg | Control | 1.33 ± 0.27 | 2.58 ± 0.16 | 11.94 ± 1.99 | 3.90 ± 0.34 | 4.13 ± 0.01 | 3.34 ± 0.07 |
| CIP | 0.83 ± 0.06a | 1.89 ± 0.14a | 14.22 ± 0.42a | 3.60 ± 0.13 | 4.58 ± 0.07 | 3.47 ± 0.05c | ||
| 250 mg/kg | Control | 0.86 ± 0.08 | 2.82 ± 0.17 | 13.20 ± 0.55 | 4.18 ± 0.07 | 3.68 ± 0.01 | 3.19 ± 0.13 | |
| CIP | 0.87 ± 0.06 | 1.97 ± 0.07a | 14.72 ± 0.81a | 3.65 ± 0.10 | 4.95 ± 0.09a | 4.24 ± 0.08a |
Results are expressed as the percentage of the control protein (GAPDH). Numbers are shown as the mean ± SEM with n = 2 for the controls and n = 3 for the CIP-treated. VE = vitamin E.
a
Values from CIP-fed mice are significantly different from respective untreated controls (p<0.05).
b
p50−/− values are significantly higher than p50+/+ (p<0.05).
c
Denotes statistical significance from the p50−/− high vitamin E group treated with CIP (p<0.05).