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Validation of the predicted PPI network based on shared GO annotations. The percentage of interactions sharing GO terms at various depths in the GO hierarchy is compared with randomly generated networks of the same group of proteins. For instance, 80.8% (8,310/10,288) of the predicted PPIs share at least one GO term at depth three in the GO hierarchy, while the largest proportion in the 1,000 randomized networks is 74.6% (7,676/10,288).
