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. Author manuscript; available in PMC: 2009 May 1.
Published in final edited form as: Chem Biol. 2008 May;15(5):467–475. doi: 10.1016/j.chembiol.2008.03.012

Figure 3.

Figure 3

Wall-eyed stereoview of superimposed product and intermediate. The product complex structure (blue) (Murray-Rust et al., 2001) is superimposed over the covalent intermediate structure (green), with the active site ligands shown in ball and stick representations. At the bottom of the figure, Asp66 forms two hydrogen bonds with each species. An ordered water molecule (Wat143) in the product complex (missing in the intermediate structure) is within hydrogen bonding distance with the imidazole of His162 (also missing in the H162G intermediate structure). The angles of the intersecting planes formed by the urea (of the product) and the thiouronium (intermediate) groups are offset by approximately 30°. The stereoimage was prepared using UCSF Chimera (Pettersen et al., 2004).