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Simplified reaction scheme for A) wild type DDAH catalyzed hydrolysis of Nω-methyl-L-arginine and B) H162G DDAH catalyzed turnover of S-methyl-L-thioctirulline. The boxed structure represents the crystallized adduct which can be partitioned into either the hydrolysis product (citrulline, upper route) or to amidinotransferase products (lower route) depending on the chemical rescue reagent.
