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. Author manuscript; available in PMC: 2009 Apr 1.
Published in final edited form as: Autophagy. 2008 Feb 1;4(3):391–394. doi: 10.4161/auto.5661

Figure 1.

Figure 1

Schematic representation of experimental design to determine the role of autophagy in drug-induced cell death. The extent of protection/potentiation caused by autophagy knockdown can provide an estimate of how much of the death is dependent upon autophagy. The curves show typical cases where inhibition of autophagy is not completely effective and the role of autophagy may not be absolute. In an extreme case where all cell death was due to autophagy, complete inhibition of autophagy might provide complete protection against the stimulus at all doses.