TABLE 2.

TIMELINE OF SEVERAL KEY GATA-1 OBSERVATIONS (NOT LISTED IN TABLE 1)

YEAR	OBSERVATION/FINDING	REFERENCES
1988	GATA-1 first identified as an erythroid nuclear protein (named Eryf1)	Evans et al., 1988
1989	Cloning of GATA-1and structural evidence (C-f)	Tsai et al., 1989
1990	Expression of GATA-1 in MK and mast cells	Martin et al., 1990
1990	GATA-1 location identified on the × chromosome	Zon et al., 1990
1991	GATA-1 mutations block erythroid differentiation	Pevny et al., 1991
1994	GATA-1 might be essential only in later primitive erythroid precursors	Weiss et al., 1994
1995	GATA-1 is predominant GATA factor for erythroid maturation	Pevny et al., 1995
1996	GATA-1 mutation study shows that GATA-1 plays an essential role in terminal erythroid maturation	Fujiwara et al., 1996
1997	Megakaryocyte growth and platelet development (lineage-selective GATA-1 knockdown)	Shivdasani et al., 1997
2002	Structural evidence (N-f) of GATA-1	Chang et al., 2002
2002	GATA-1 in eosinophil development	Hirassawa et al., 2002
2003	GATA-1 is a regulator of mast cell differentiation	Migliaccio et al., 2003
2006	Chromatin remodeling affects GATA-1 expression	Grass et al., 2006